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Married woman alleges gang rape, in Kalol

VADODARA: A woman residing at Bakrol village in Kalol taluka of Panchmahal district was allegedly raped by four persons, including a juvenile boy.

The four were arrested by Kalol police in connection with the offence.

The 23-year-old married victim was passing by a deserted farm in the early hours on Sunday when she was raped. The woman approached police with her complaint in the early hours of Wednesday following which the accused were arrested.

According to the woman, she was stopped and held by the juvenile boy. Three other accused Deepaksinh Parmar, Bhailu Parmar and Umesh Parmar reached the spot and dragged her into the farm. Her mouth was gagged by the accused using their hands.

The rape survivor claimed that the accused raped her one after the other. Bhailu and Umesh also clicked pictures of her during the crime. The accused allegedly threatened to kill her and her family members if she mentioned about the incident to anybody.

The police arrested the accused on Wednesday itself and presented them in a local court.

Three of the accused were sent to judicial custody while the juvenile accused was sent to the observation home. Medical tests will be conducted on the accused as a part of the investigations, sources said.

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Anti-allergic activity of compounds from Kaempferia parviflora

Kaempferia parviflora is one of the plants in the Zingiberaceae family, locally known in Thai as kra-chai-dam. In Thai traditional medicine, the decoction of Kaempferia parviflora powder with alcohol has been reported to cure allergy, asthma, impotence, gout, diarrhea, dysentery, peptic ulcer and diabetes. Therefore, the present study aimed to investigate anti-allergic substances from this plant. Bioassay-guided fractionation led to the isolation of seven methoxyflavone derivatives (1–7) from Kaempferia parviflora extract and they were identified on the basis of spectroscopic methods. Among the compounds tested, 5-hydroxy-3,7,3',4'-tetramethoxyflavone (5) possessed the highest anti-allergic activity against antigen-induced ß-hexosaminidase release as a marker of degranulation in RBL-2H3 cells with an IC50 value of 8.0 µM, followed by 5-hydroxy-7-methoxyflavone (2, IC50 = 20.6 µM) and 5-hydroxy-7,4'-dimethoxyflavone (4, IC50 = 26.0 µM), whereas others showed moderate activities (IC50 = 37.5–66.5 µM). Structure–activity trends of 7-methoxyflavone derivatives on anti-allergic activity can be summarized as follows: (1) substitution with vicinal methoxyl groups at positions 3' and 4' conferred higher activity than only one methoxylation, (2) methoxylation at position 3 reduced activity and (3) methoxylation at position 5 showed higher activity than hydroxylation. Compounds 2, 4 and 5 were also determined for their mechanisms on ionomycin-induced ß-hexosaminidase release. The results indicated that the mechanism on inhibition of cell degranulation of compounds 2 and 5 mainly involve the inhibition of Ca2+ influx to the cells, whereas that of 4 may be partly due to this inhibition.

In regards to the active constituents for anti-allergic activity of Kaempferia parviflora, 5-hydroxy-3,7,3',4'-tetramethoxyflavone (5), 5-hydroxy-7-methoxyflavone (2) and 5-hydroxy-7,4'-dimethoxyflavone (4) are responsible for anti-allergic effect of this plant. The findings support the traditional use of Kaempferia parviflora rhizomes for treatment of allergy and allergy-related diseases.

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